Safety and pharmacokinetics of milademetan, a MDM2 inhibitor, in Japanese patients with solid tumors: A phase I study - Takahashi - 2021 - Cancer Science - Wiley Online Library
Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study - ScienceDirect
Cancers | Free Full-Text | Ibrutinib Associated with Rituximab-Platinum Salt-Based Immunochemotherapy in B-Cell Lymphomas: Results of a Phase 1b-II Study of the LYSA Group
Recommended dosages in each arm. DLT, dose-limiting toxicity; RD,... | Download Scientific Diagram
Determining drug dose in the era of targeted therapies: playing it (un)safe? | Blood Cancer Journal
1. Given the true DLT rate, calculate the probability | Chegg.com
Study Design. DLT-dose limiting toxicity; MTD-maximum tolerated dose | Download Scientific Diagram
Outline
Dose-Finding Schemes in Clinical Trials
Exposure driven dose escalation design with overdose control: Concept and first real life experience in an oncology phase I trial - ScienceDirect
Would the Recommended Dose Have Been Different Using Novel Dose-Finding Designs? Comparing Dose-Finding Designs in Published Trials | JCO Precision Oncology
Flexibility of the BLRM in Dose-Escalation Trials
Three-plus-three dose escalation design. DLT, dose-limiting toxicity;... | Download Scientific Diagram
Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study - ScienceDirect
Illustration of the chronic dose-limiting toxicity (DLT) concept. (*)... | Download Scientific Diagram
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Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study. - Abstract - Europe PMC
Adaptive designs for dual-agent phase I dose-escalation studies | Nature Reviews Clinical Oncology
Study design for dose-escalation cohorts and DLT rate (as calculated by... | Download Scientific Diagram
Diagram of the inter-subject or inter-cohorts' escalation. DLT:... | Download Scientific Diagram
Phase I trials - memoinOncology
Early phase clinical trials to identify optimal dosing and safety - Cook - 2015 - Molecular Oncology - Wiley Online Library
DURVIT': a phase-I trial of single low-dose durvalumab (Medi4736) IntraTumourally injected in cervical cancer: safety, toxicity and effect on the primary tumour- and lymph node microenvironment | BMC Cancer | Full Text
Dose Limiting Toxicities (DLT) DOSE LIMITING TOXICITIES (DLT) Example: Dose escalation will proceed within each cohort according
1. In a typical Phase I clinical trial of a new drug, | Chegg.com
Study protocol: phase 1 dose escalating study of Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) with oxaliplatin in peritoneal metastasis
